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KOTB, A., SALEH, A., HELAL, M., .SHAHEIN, N., KHODEIR, M. (2018). IN VITRO EFFECT OF DIFFERENT INACTIVATORS ON RABIES VIRUS. Egyptian Journal of Agricultural Research, 96(2), 211-220. doi: 10.21608/ejar.2018.153331
ATTYAT M. KOTB; AMANI A. SALEH; MONA A. HELAL; NORA E. .SHAHEIN; MOHAMED H. KHODEIR. "IN VITRO EFFECT OF DIFFERENT INACTIVATORS ON RABIES VIRUS". Egyptian Journal of Agricultural Research, 96, 2, 2018, 211-220. doi: 10.21608/ejar.2018.153331
KOTB, A., SALEH, A., HELAL, M., .SHAHEIN, N., KHODEIR, M. (2018). 'IN VITRO EFFECT OF DIFFERENT INACTIVATORS ON RABIES VIRUS', Egyptian Journal of Agricultural Research, 96(2), pp. 211-220. doi: 10.21608/ejar.2018.153331
KOTB, A., SALEH, A., HELAL, M., .SHAHEIN, N., KHODEIR, M. IN VITRO EFFECT OF DIFFERENT INACTIVATORS ON RABIES VIRUS. Egyptian Journal of Agricultural Research, 2018; 96(2): 211-220. doi: 10.21608/ejar.2018.153331

IN VITRO EFFECT OF DIFFERENT INACTIVATORS ON RABIES VIRUS

Article 31, Volume 96, Issue 2, July 2018, Page 211-220  XML PDF (458.94 K)
Document Type: Original Article
DOI: 10.21608/ejar.2018.153331
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Authors
ATTYAT M. KOTB1; AMANI A. SALEH1; MONA A. HELAL2; NORA E. .SHAHEIN2; MOHAMED H. KHODEIR1
1Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt
2Faculty of Girls for Arts, Science and Education, Ain Shames University.
Abstract
ascorbic acid, Beta propilacton and binary ethylenamine (BEA) were evaluated as inhibitors of rabies' virus (Evely- Retkitincki-Abeleseths skauis) in optimized BHK21 cell cultures. Ascorbic acid inactivated rabies virus at concentrations of 0.1, 0.5 and1mg/ ml after 22,18 and 14 hours at 37o C respectively, while BPL inactivated the virus after 4,6,8 hours with concentrations of 1/500,1/10000,and1/20000 respectively at 37oC. BEI inactivated the virus after 6 hours when used with 0.3 M. These Inactivators did not affect the antigincity of rabies virus in three prepared experimental vaccine batches. Ascorbic acid appears to be the most preferable one as safe natural noncarcinogenic agent when compared with BPL and BEI.
Keywords
INACTIVATORS; RABIES VIRUS
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