SUBACUTE HISTOPATHOLOGICAL EFFECTS OF ALPHACYPERMETHRIN TECHNICAL AND ITS FORMULATION SUPER ALFA 10% EC ON LIVER, KIDNEY AND THYROID IN MALE ALBINO RATS

Document Type : Original Article

Authors

Central Agricultural Pesticides Laboratory, Agricultural Research Center, Dokki, Giza, Egypt.

Abstract

In the present study four groups of experimental rats were treated with two different doses of technical alphacypermethrin 96% (10.5, 5.25 ppm represent 1/10, 1/20 of determined L050) and two other doses of its formulation Super Alfa 10% EC (1.2, 0.6 ppm represent 1/10, 1/20 of determined LD50) orally for 28 consecutive days. Then samples of livers, kidneys and thyroid glands of all groups were taken and histopathologically examined. The results showed more adverse effects of technical alphacypermethrin on the liver tissue than the EC formulation, where both used doses of them produced bleeding and cirrhosis in parts of liver tissue and increasing the division of some cells. Also more effects on kidney tissues by the technical than the EC formulation and with the high doses were produced. Most kidney damages were congestion of capillaries and blood vessels and the presence of bleeding and fibrosis. The technical produced atrophy in a large number of vesides in the thyroid tissue by the high dose, where in case of EC formulation the examination showed the glue absence in some cells of the thyroid by the high dose only.

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