TRIALS FOR PREPARATION OF INACTIVATED BIVALENT AVIAN ENCEPHALOMYELITIS AND REO VIRUS VACCINE

Document Type : Original Article

Authors

Veterinary Serum and Vaccine Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki, Giza, Egypt

Abstract

Inactivated monovalent and bivalent oil adjuvanted vaccines against Avian Encephalomyelitis (AE) and Reo viruses were prepared. Immunological responses to such experimental vaccines were evaluated by injecting them into groups of susceptible thickens. Blood samples were collected at weekly intervals. Serological and cellular immune response were evaluated by SNT, lymphocyte blastogenesis and macrophage activity test, respectively. The vaccinated chicks were subjected to challenge tests against both viruses. The results indicated that prepared vaccine was effident, safe, immunogenic and produced satisfactory dual protection against AE and Reo viruses infection.