EVALUATION OF FOWL CHOLERA VACCINE BY MICE VACCINATION AND CHALLENGE INOCULATION SYSTEM

SHAFEI, SAMY M.; EL-EBIARY, ELHAM A.; ROFAIIL, SAFWAT K.; GERGIS, SAHER M.

doi:10.21608/ejar.2003.276332

EVALUATION OF FOWL CHOLERA VACCINE BY MICE VACCINATION AND CHALLENGE INOCULATION SYSTEM

Document Type : Original Article

Authors

¹ Central Laboratory for Control of Veterinary Biologics, Agricultural Research Centre, Dokki, Giza, Egypt

² Veterinary Serum and Vaccine Research Institute, Agricultural Research Centre, Dokki, Giza, Egypt

10.21608/ejar.2003.276332

Abstract

In the present study, S lots of commercial fowl cholera vaccines were evaluated by different methods. Results indicated that the lots failed to pass the two stages protection test in chicken. Comparable results were obtained by conducting either active immunization in mice or by the mouse vaccination challenge inoculation system. From the obtained results it can be concluded that mice can be used instead of chickens for evaluating fowl cholera vaccines as they are more cheaper and less susceptible to viral diseases that may complicate the evaluation test procedure in chicken.