EFFECT OF ANTIOXIDANT ON HEPATIC FATTY ACID PATTERN IN VITAMIN E-DEFICIENT RATS

The present investigation aims to find a proper answer whether can the antioxidant effect of vitamin E be substituted by the antioxidant effect of high levels of vitamin C. A or selenium Ion using the fatty acid pattern of liver as an indicator for lipid peroxidation?. Rats were fed o a standard diet containing vitamin E stripped cons or cotton seed oils for 49 days. Excess amounts of vitamin A (0.45 giclay). vitamin C (7.5 mg/ day), sodium selenito (0.1 mg/clay). or water were daily administered by a stomach tube. Normal rats led on diet containing corn or cotton seed oil for 6 weeks were used as control groups. Fatty acid composition of tho liver was determined by gas-liquid chromatography technique. There was . significant decrease in CI to in vitamin Egeticient corn oil group and it was completely absent in vitamin E-deficient cotton seed oil group with Increase the C16^.0 and Ci a 1. Administration of vitamin A in the Presence of vitamin E-stripped cotton seed oil, gave satisfactory results by increasing of C15.2 and decreasing Of Ciao and Citi. White. in the Presence of vilemin &stripped corn oil, the autexidation of Cigo was in­creased. therefore Shen chain fatty acids were present relatively in large amounts compared to its control group (corn oil group). Administration of vitamin C in the presence of vitamin Elliippecl Corn oil Significantly in­creased hepatic Meant acid from Si% to 46.6% and oleic acid from 3.7% to 11.1%. Administration of Wend° ion to the sane group moder­ately increased,steanc. oleic and linoteic adds. &Nears ion was the best additive to vitamin E-stripped corn oil and it improved the pattern of fat­ty adds Containing eighteen carbon atoms _(Ciao C15_:1, C15.2). In the case of vitamin E-deltcient rats fed on cotton Seed oi Kw from vitamin E. administration of vitamin C or solonite ion gave the best results. in which, the fatty acid patterns beeline Similar to its control group (Col­ton seed oil groups).