EFFECT OF CLOSTRIDIAL ANTIGENS CONCENTRATION ON THE IMMUNE RESPONSE IN SHEEP AND RABBITS

Document Type : Original Article

Authors

Veterinary Serum and Vaccine Research Institute, Agricultural Research Centre, Giza, Egypt

Abstract

A bivalent vaccine of aperfringens types B and D and a polyval­ent one containing six antigens (Uperfringens types B and D, Cf. septi­cum, Ci.chauvoei, Cf.noryi type B and a tetani were prepared and con­centrated by using ultrafiltration system. The vaccines were tested in rabbits and sheep. The immune response for concentrated vaccines was better than unconcentrated one. Also, formalin consumption was not af­fected by concentration.