STUDIES ON CHRONIC HEPATITIS: 1- LIPID PROFILE OF CHRONIC C HEPATITIS AFFECTED PATIENTS WITH SPECIAL REFERENCES TO SERUM TRACE ELEMENTS

Document Type : Original Article

Authors

1 National Research Centre, Egypt

2 Faculty of Agriculture, El-Minia University, Egypt

3 Animal Health Research institute, Agricultural Research Centre, Dokki, Giza, Egypt

Abstract

This study was conducted on 50 male subjects with an age rang­ing 31 to 54 years with mean of 43.6 ± 8.1, divided into two groups: group one included 30 male subjects with the diagnosis of chronic hepa­titis C, and group two included 20 age matched normal volunteers. Both groups were subjected to clinical examination, liver functions, abdominal sonography, polyrnorase chain reaction (PCR) for Hepatitis C virus (FICV), determination o/ serum iron, zinc. copper, and magnesium, lipoprotein profile. In addition patients, group were subjected to liver biopsy and es­timation of histology activity index. Results showed no significant differ­ence between patients mean serum iron (129.2 ± 41 ug/ dl) and control (101.45 ± 33.5 ug/c11) 'P < 0,269'; between patients mean serum cop­per (105.4 = 27_6 ug/dI) and control (104.95 ± 24.29 ugf dl) P < 0.359", between patients mean serum zinc level (140.6 ± 12.6 ug(dl) and control (137.63 ± 14.06 ug/dI) P < 0.347", between patients mean serum magnesium (20.817 ± 2.924 ug/dI) and control (21.66 ± 2.33 ugid1): P = 0,24". Lipoprotein profile showed no significant differ­ence between serum cholesterol. triglycerides, LDL, HDL in both groups_ We found elevated serum iron in 6 patients (20%), elevated serum cop­per in 5 patients (16.7%) and elevated serum magnesium in two pa­tients (6.7%) in diseased group. Only HDL showed significant positive correlation with histological activity index (Pe 0.01)_ in conclusion, there is no correlation between studied serum trace elements and severity of chronic hepatitis.

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