IMMUNE RESPONSE OF BUFFALO-CALVES TO INACTIVATED COMBINED VACCINE UNDER FIELD CONDITIONS

Document Type : Original Article

Authors

Veterinary Serum and Vaccine Research Institute, Agricultural Research Centre, Giza, Egypt

Abstract

Fourteen buffalo-calves each was vaccinated twice within 2 weeks interval with 3 ml of the reconstituted inactivated combined vac­cine. The vaccinated calves were kept for 6 months in a natural setting with five non-vaccinated control calves. All vaccinated calves remained clinically normal during the observation period, 3 control calves devel­oped symptoms of respiratory disorders and PI - 3 virus was isolated from the nasal discharge of only 2 control animals. IBR virus was isolated at 45 days post-vaccination from the third one, and showed titer of 1­22 after 2 months, while BVD virus was not isolated from any calf. Re­sults of the SN test against IBR, BVD and PI - 3 antigens indicated that, efficacy of vaccine and the calves should be revaccinated each 6 months from vaccination.