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EL-GENDY, K., EL-SEBAE, A., ALY, N., RASHWAAN, E. (1999). BIOCHEMICAL TARGETS AFFECTED BY SUBLETHAL DOSES OF CYPERMETHRIN IN MICE. Egyptian Journal of Agricultural Research, 77(2), 701-711. doi: 10.21608/ejar.1999.332478
KAWTHER EL-GENDY; ABDEL-KHALEK H. EL-SEBAE; NAGAT ALY; EIMAN RASHWAAN. "BIOCHEMICAL TARGETS AFFECTED BY SUBLETHAL DOSES OF CYPERMETHRIN IN MICE". Egyptian Journal of Agricultural Research, 77, 2, 1999, 701-711. doi: 10.21608/ejar.1999.332478
EL-GENDY, K., EL-SEBAE, A., ALY, N., RASHWAAN, E. (1999). 'BIOCHEMICAL TARGETS AFFECTED BY SUBLETHAL DOSES OF CYPERMETHRIN IN MICE', Egyptian Journal of Agricultural Research, 77(2), pp. 701-711. doi: 10.21608/ejar.1999.332478
EL-GENDY, K., EL-SEBAE, A., ALY, N., RASHWAAN, E. BIOCHEMICAL TARGETS AFFECTED BY SUBLETHAL DOSES OF CYPERMETHRIN IN MICE. Egyptian Journal of Agricultural Research, 1999; 77(2): 701-711. doi: 10.21608/ejar.1999.332478

BIOCHEMICAL TARGETS AFFECTED BY SUBLETHAL DOSES OF CYPERMETHRIN IN MICE

Article 15, Volume 77, Issue 2, March 1999, Page 701-711  XML PDF (2.25 MB)
Document Type: Original Article
DOI: 10.21608/ejar.1999.332478
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Authors
KAWTHER EL-GENDY1; ABDEL-KHALEK H. EL-SEBAE1; NAGAT ALY2; EIMAN RASHWAAN3
1Department of Pesticide Chemistry, Faculty of agriculture, Alexandria University, Egypt
2Central Agricultural Pesticides Laboratory, Agricultural Research Centre, Dokki, Egypt
3Medical Research Institute, Alexandria University, Egypt
Abstract
The effects of repeated sublethal doses of cypermethrin (0.25 mg/Kg/day) for 14 days on some haematological, biochemical and im­munological parameters in male mice were investigated 1 hour, 24 hours, 1,3 and 5 weeks after the last dose. No significant changes were recorded in hemoglobin content (1-1b), haematccrit value (Hct) and red blood cells count (BBC's). Only white blood cells count (WBC's) signifi­cantly increased 3 and 5 weeks after the last dose. The activities of the tested enzymes; adenosine triphosphatase (ATPase), carboxyfesterase (CaE), glutathione 5-transferase (GST), acid phosphatase (AcP), alkaline phosphatase (Alp), alanine transaminase (AIT) and aspartate transaminase (AsT) in treated choshen organs of male mice were increased gradually. Cypermethrin caused a pronounced direct suppressive effect on cellular immunity as illustrated by lympho­cyte proliferation to mitogens and phagocytic activity. Also, humoral im­munity as indicated by plaque forming cells (PFC) and haemagglutinating titre were suppressed. The suppressive effect of cypermethrin on im­mune response was time dependent.
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