BIOCHEMICAL TARGETS AFFECTED BY SUBLETHAL DOSES OF CYPERMETHRIN IN MICE

Document Type : Original Article

Authors

1 Department of Pesticide Chemistry, Faculty of agriculture, Alexandria University, Egypt

2 Central Agricultural Pesticides Laboratory, Agricultural Research Centre, Dokki, Egypt

3 Medical Research Institute, Alexandria University, Egypt

Abstract

The effects of repeated sublethal doses of cypermethrin (0.25 mg/Kg/day) for 14 days on some haematological, biochemical and im­munological parameters in male mice were investigated 1 hour, 24 hours, 1,3 and 5 weeks after the last dose. No significant changes were recorded in hemoglobin content (1-1b), haematccrit value (Hct) and red blood cells count (BBC's). Only white blood cells count (WBC's) signifi­cantly increased 3 and 5 weeks after the last dose. The activities of the tested enzymes; adenosine triphosphatase (ATPase), carboxyfesterase (CaE), glutathione 5-transferase (GST), acid phosphatase (AcP), alkaline phosphatase (Alp), alanine transaminase (AIT) and aspartate transaminase (AsT) in treated choshen organs of male mice were increased gradually. Cypermethrin caused a pronounced direct suppressive effect on cellular immunity as illustrated by lympho­cyte proliferation to mitogens and phagocytic activity. Also, humoral im­munity as indicated by plaque forming cells (PFC) and haemagglutinating titre were suppressed. The suppressive effect of cypermethrin on im­mune response was time dependent.

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